CCAC guidelines are intended to provide assistance in the implementation of Russell and Burch’s Three Rs (Replacement, Reduction and Refinement) principles for animals in science (Russell and Burch, 1959). ILAR Journal Vol 31, Issue 4, p. 5-20; Rat - Blood draw video (saphenous vein, cardiac puncture) within 20 s), rats spent 13 s in isoflurane but only 1 s in CO 2. PURPOSE This Standard Operating Procedure (SOP) describes guidelines for the management of rat breeding colonies. 3. When using oil or viscous gel adjuvant (e.g., FCA) in rabbits, mice or rats, SC is the recommended route. Guidelines of the CCAC Since the first Guide to the Care and Use of Experimental Animals was published in 1968, the guidelines of the CCAC have steadily evolved in response to new information or … In general terms the CCAC recommends that ... 17mm, width 17mm) tumour for rats. 2. h��V{lS�?��3Əkǐ�Iӛpq��[��AR�. Pail. Standard operating procedures, policies, and guidelines help educate individuals on the proper and current techniques accepted. The CCAC conducts assessment visits to each participating institution using animals. CCAC guidelines establish the basic requirements for each institutional program within the Canadian system of oversight of animal ethics and care. CCAC Guidelines: The current CCAC guidelines indicate that for cancer research the experiment must be designed with endpoints that minimize the potential for pain and/or distress. // stream
Rats were sacrificed on the 7th and 14th days for pathological examination of the wound. This procedure will administer the compound into the distal esophagus where it will then enter the stomach. Daily Canadian Council on Animal Care. Agricultural Research; CCAC guidelines on : the care and use of farm animals in research, teaching and testing; Other resources. Goals for successful euthanasia include techniques requiring minimal restraint, simplicity Skinner's study of behavior in rats was conducted under carefully controlled laboratory conditions Summary of Guidelines CCAC guidelines: Rats 3 3. Guidelines for the use of animals in cancer research This is a selection of guidelines in the public domain that address the care and use of animals in cancer research, including the issue of … CCAC resources. CCAC guidelines: Rats 1 PREFACE The Canadian Council on Animal Care (CCAC) is the national peer-review organization responsible for setting and maintaining standards for the ethics and care of animals in science throughout Canada. 1989. Subcutaneous (SC or SQ) Injection in Rats and Mice SOP Purpose This Standard Operating Procedure (SOP) describes the procedure of subcutaneous injections into rats and mice. Excellence in research is based on outstanding science and adherence to ethical, professional, and regulatory standards associated with the conduct of studies. methods, to achieve “euthanasia”, for rats and other laboratory animals are ongoing, as reflected in recent updates to the Canadian Council on Animal Care (CCAC) and American Veterinary Medical Association (AVMA) eu-thanasia guidelines [3, 4]. AVMA Guidelines for the Euthanasia of Animals: 2020 edition; CCAC guidelines on "Choosing an appropriate endpoint in experiments using animals for research, teaching and testing". When placing rats in a warmed box, it is essential that the 0
Alberta Government, Agriculture and Rural Development (2007) Firm Steps: Identifying Lameness in Dairy Cattle.Edmonton AB: Alberta Agriculture and Food. Rats spent an average of 47 s in cages filled with air. 4146 0 obj
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2010; McGuill MW, Rowan AN. Viscous adjuvants should never be given IV due to the risk of thrombosis and pulmonary embolism. Oral Dosing (Gavage) in Adult Mice and Rats SOP . This bibliography was generated on Cite This For Me on Tuesday, January 27, 2015 The CCAC comprises 22 member organizations, whose presentatives include scientists, educators, veterinarians and delegates from industry and the animal welfare movement. RESPONSIBILITY Principal investigator (PI) and their research staff, animal care staff and veterinary care staff. Purpose . Agricultural Research; CCAC guidelines on : the care and use of farm animals in research, teaching and testing; Other resources. ... An investigator has developed a thorough analgesic protocol for experimental surgery on rats. Physiological normal values (Depends on age, strain, health status, type of anesthesia, etc.) The CCAC guidelines: Rats (CCAC, 2020) note that exposing rats to carbon dioxide for euthanasia is likely to cause pain and distress (Leach et al., 2004; Moody et al., 2014). Paper towel. %%EOF
190 O'Connor St, Suite 800 Purpose: to ensure each rat room and shoebox cage is maintained daily, weekly, and monthly care of rat rooms. Disinfectant: Lemon Quat TM, U974. emailE=('ccac@' + 'ccac.ca') Compliance with CCAC guidelines and policies is a requirement to receive a CCAC Certificate of GAP – Good Animal Practice®, as determined by CCAC assessment panels. Rats Mice. Ethics of animal investigation (CCAC, 1989) Scientific merit and ethical review of animal-based research (CCAC, 2013) Terms of reference for animal care committees (CCAC, 2006) Assessment panels (CCAC, 2006) Ethical principles and guidelines for experiments on animals (Switzerland, 1995) Education & Training Education and Training (2014). j�\����@�Ny���N�1�����o�� It is recommended to keep gestating and lactating rat dams, and pups up to 3‐4 weeks old, at the higher end of the recommended temperature range (24‐26C), as they have reduced thermoregulatory ability. the CCAC program are discussed in more detail in following sections. Responsibility document.write('
' + emailE + '<\/a>') Ottawa, ON, K2P 2R3 // ]]>, Certificate of GAP – Good Animal Practice, National and International Three Rs Centres, Three Rs of Humane Animal Experimentation, Laboratory Animals Used in Biomedical Research, CCAC Certificate of GAP – Good Animal Practice. [CDATA[ !�v���h��p��P�- Policy: Laurentian University and CCAC guidelines and Regulations. 4128 0 obj
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This is a user guide for the Ratnoze portable sampling system. As the guidelines are updated, they will be removed from this Guide and the new guidelines will be posted on the CCAC website under the appropriate heading. The main conflict of the story is when rats living in the city dump is mutated (from gases) Construction Cost Summary Template and wreaks havoc on the citizens of the city. It is appropriate for emission measurements of brick kilns, and other large and small scale industrial combustion sources with and without exhaust stacks. The guidelines contained within the Guide to Care and Use of Experimental Animals, vol 1, 2nd edition (1993) are currently being revised. CCAC resources.
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|�����Y\*hdE�wQ��$0��D5�կ�=����A8�E����29�r�4 Assessments are based on several documents, including the CCAC guidelines and policies. Three Rs information and additional resources such as frequently asked questions (FAQs) are intended to support the implementation of the guidelines and to encourage institutions to evaluate new practices to enhance their animal ethics and care programs. Materials. Which one if the following approaches is in use in Canada by participants in the CCAC Program? 2. The CCAC guidelines: Rats provides information for investigators, animal care committees, facility manag- This Standard Operating Procedure (SOP) describes the procedure of orally dosing rats and mice. Guidelines for the Survival Bleeding of Mice and Rats. (1998) Canadian Council on Animal Care, Canada; Guide for the care and use of laboratory animals. �Z0:Bn�@q�-�^~�uX�OdcHކ��P?x�T�3i�//���.�kb����d{�$u�a&F�TLR�m8�{`e�Ǯ@]kX��!����[��t��`�z�H��˔���f� �`3��'��g���^�[��/��LI�z��F��2^�{�R���8��q�,�H[*��Spˌ�� ����Txw{�U5&�n��-e��5��6�]����.���6���mv��m+���Y���[����=�$���a�e']R��X=/���BaQ��X���MxF!OCV��uOx�������G��x=I�J��Ęݧ����u�L�1�?�gd8\M��D1Y漶�s�d��9B�7o�X��7�B����0���.2,V�%R/�%y�UN���V�cBDUr}����Y��!�Ӂ���^�[�]����:�w� �T%��N�S��=����9�{n�,��)�����۠
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MATERIALS 3.1. The CCAC guidelines: Rats, states that the basic needs include group housing, shelters, and sufficient space to accommodate these elements and the expression of behaviors important to rat welfare. endstream
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